Saturday, February 4, 2017

The researchers ' supercharge ' antibiotics to rip each other's super bugs: study hailed as ground-breaking in the race against drug resistance

Scientists have found a way to supercharge antibiotics to "blow up" super bugs.


Researchers have found that the use of certain medications with sufficient force has the power to tear up the bacteria from one another, thus killing them.

Typically, binding of antibiotics for the bacterial cells to destroy them such as putting the key in the lock of the door.

When bacteria become resistant to one drug, it's as if the key has been changed so that the key is no longer suitable.

But the researchers found that the drug performed like a physical force on the bacteria that ' tore the door off the hinges. '

A study at University College London, looked at Vancomycin, a powerful antibiotic that is used as a last resort treatment for MRSA, and oritavancin, a modified version of Vancomycin is used to fight skin infections.

The researchers found that oritavancin presses become resistant bacteria with the power of 11,000 times stronger than Vancomycin, despite having the same key.

Oritavancin can kill bacteria in 15 minutes instead of Vancomycin, which takes between six and 24 hours.

Lead author Dr. Joseph Ndieyira of University College London said: ' some antibiotics are so strong, they ripped off doors with hinges, kill the bacteria directly.

Our research shows that the strength of oritavancin generates can really tear holes in the bacteria and they tore apart.

Our results will help us not only to design new antibiotics but also to modify the overcome resistance.

He explained that the molecules of oritavancin remains very well together and form a group that explores the surface of bacteria, ripping it and kill him.

The researchers also found that the conditions on the surface of bacteria to encourage grouping, which in turn make antibiotics more effective.

Scientists are looking for other antibiotics with similar properties to create a new generation of drugs that are capable of defeating even the most resistant super bugs.

The growing crisis of antibiotic resistance, in which the bacteria change in ways that reduce the effectiveness of antibiotics, have cost the public health on the edge.

The Centers for Disease Control and prevention called the antibiotic resistance is one of the most urgent public health threat of our time, while the UNITED NATIONS SUMMIT last year pronounced that is equivalent to the spread of Ebola and HIV.

The development of antibiotic resistance has been driven by several factors, including excessive prescription drugs to the virus, (which isn't very bacteria and therefore not effective in treatment), the correct prescription and dosage, and drug use in agriculture.

Antibiotics have been used to promote growth in farm animals.

Reports have emerged of bacteria resistant to even the ' last resort ' antibiotics such as colistin, and even superbugs releasing decoy molecules that allow them to escape being killed by drugs.

This has forced researchers to either create a new antibiotic or to find a way that exists still to be effective

A study conducted last year at the University of Texas Southwestern Medical Center, found that the superbug dazzling using GM substance, so they are not able to find the places where they usually will remain into the host body, proved more effective than killing them.
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