between adjacent cells
Scientists say that they have shed new light on how a common analgesic acetaminophen
causes liver damage when used in excess.
They believe that their findings could inform further research into therapies to counteract
the damage caused by excessive doses of drugs – the leading cause of acute liver disorders
in the Western world.
Too much acetaminophen poisoning can be difficult to treat and can even be fatal.
Scientists from the University of Edinburgh studied the impact of pain medication on a
network of mouse liver cells and in human beings.
The tests showed that in a certain configuration, acetaminophen can damage the liver by
damaging important relationships between the structure of adjacent cells in the body.
When this connection is the cell wall – known as narrow joints-disturbed, structure damaged
heart tissue, the cells cannot function properly and they can die.
Scientists say that this type of cell damage known to occur in the condition of the liver,
hepatitis, cirrhosis and cancer, but not acetaminophen toxicity has been associated with so
far.
The researchers say they are now trying to examine how various doses of paracetamol and
deadlines affect the liver toxicity and identified potential targets for new drugs.
Dr. Leonard Nelson, Hepatology of the University laboratory and Institute of biotechnology,
co led the study, said: "the world the choice of pain medication-it's cheaper and
considered to be a therapeutic dose is safe and effective.
"However, drug-induced liver damage remains an important clinical problems and challenges
for the development of safe drugs.
"Our results reinforce the need for vigilance in the use of paracetamol and can help find
how can prevent the damage caused by the use of bad."
Author Pierre Bagnaninchi, MRC Centre for regenerative medicine at the University, added:
"Although liver damage from acetaminophen toxicity has been the subject of intense study
for 40 years, the latest developments in the technology of biosensor enables a more
complete picture of the biological mechanisms that are involved."
Research, researchers from Edinburgh and Oslo and the Scottish National blood transfusion
service, was published in the magazine scientific report.
It is partially supported by the study of biotechnology and biology and head scientist of
the Council Office.
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