Although anti-inflammatory drugs of non-steroid (RAINS) was found to reduce pain and make your move and make everyday activities easier, the difference compared to placebo was not large enough for scientists to consider it important. In addition, people who take the drug RAINS is at greater risk of gastrointestinal problems compared with those who got a placebo.
Back pain usually gets better by itself after a few weeks, but it might be a good idea to seek help, if your pain persists for more than this, it is getting worse or stop You doing daily activities. You should discuss treatment options with a doctor.
ANTI-INFLAMMATORY DRUGS OF NON-STEROID IS USELESS
This research is a systematic review and meta-analysis, which looked at a number of high-quality research to arrive at the conclusion that in General, NSAIDS are not effective for back pain.
But this means research RAINS doesn't work at all for back pain and should not be used. It is possible that some people will still benefit from them, with the survey showing that about one out of six people who took the drug RAINS, rather than placebo, experienced a significant reduction in pain.
Some media outlets reported the story have been exaggerated and misleading. The online message, URURf.eks, claiming "ibuprofen works for back pain" when in fact, the study found RAINS medications are effective in reducing pain, only the amount of the benefit that people feel are not believed to be a clinically important decrease compared with placebo.
The e-mail also stated that "adults take cheap pills actually are three times more likely to suffer inflammation of the stomach". In fact, these studies found NSAIDS increases the chances of digestive problems, not necessarily injured, by 2.5 times.
The study was conducted by researchers from the University of Sydney in Australia.
METHODS OF STUDY
Researchers undertake systematic literature review and meta-analysis of randomised controlled trials (RCTs) comparing the effectiveness and safety of 35 NSAIDS placebo.
The review includes RCTs, with 35 6,065 participants with acute or chronic neck or low back pain. Each class, formulation or route granting (topical, oral or injection) NSAIDS put each dose and frequency of intake of NSAIDS.
The follow-up period less than two weeks is defined as the terms soon and the follow up from between two weeks and three months as short-term.
Outcome measures reported pain in the trial that the Visual analogue scale or the scale of a numeric rating. This has been converted to a common scale, ranging from 0 to 100, with 0 meaning no pain or disability and 100 means the worst possible pain or disability.
A difference of 10 points on a 0-100 scale between placebo and the drug is considered the most feasible effects that patients understand the importance of. The 10-point difference that at least should be considered "clinically essential".
The number to process (NTT) – the number of patients who should be treated with NSAIDS than placebo for an additional person to benefit-this is also intended to provide a more understandable measure of benefits.
This study has several limitations:
# Country treatment range from the oral intake is to apply a gel or cream. Some patients
may feel better with applications directly related to oral medications, but it is hard to say
which is more effective because it was classified.
# Dose also varies between studies and therefore it is difficult to know if the drug RAINS
is more effective at higher doses.
# Treatment period on average only seven days and it is, therefore, difficult to say what the
long-term results would have been if the participant has continued to take NSAIDS.
The research is focused on whether the drug RAINS is effective for back pain as a whole, so it is difficult to know whether a particular individual or specific groups of patients may benefit more from treatment than others.
This study is not configured for comparing NSAIDS with other non-Pharmacological treatments (like exercise), some of which may be more effective than NSAIDS.
BASIC RESULTS
NSAIDS are mostly given orally, but some experimental drugs injected or using gel, patch, or
cream.
When considering the pain:
NSAIDS reduced pain and disability compared with placebo in direct (mean difference (MD)-9.2, 95% confidence interval CI-6.9 to 7.3).
NSAIDS reduced pain and disability compared to placebo in short-term (MD-95% CI 7.7, 11.4 to 4.1).
But none of these results is clinically important according to researchers as the difference between NSAID and placebo was less than the standard limit of 10 points on a 0-100 scale.
Consider what a healthy person would consider a significant reduction in pain, meaning that six individuals (95% CI 4-10) will have to be dealt with in two weeks with NSAIDS than placebo for an additional person to obtain a reduction of pain is clinically important in the short term.
When considering security, has a number of participants taking side effects on channel cornea is higher compared with placebo (relative risk [RR] 2.5, 95% CI 0.7 -5,2). There is no difference between a group of NSAIDS and placebo groups in the event of serious adverse events.
THE RESEARCHERS CONCLUSIONS
Researchers concluded that:
"RAINS gives no clinically important effects on spinal pain, and six patients were treated with RAINS for patients to reach important clinical benefits in the short term."
They added "when these results are taken together with people from the reviews on
paracetamol and an opioid, it is now clear that three of the most widely used, and the guideline-recommended medications for sore spine does not provide an important clinical the effect over placebo. There is an urgent need to develop new analgesics for pain spine. "
There is evidence that PAINS is effective in reducing pain and disability in patients with spinal pain, but treatment seems not much more effective than a placebo and not clinically significant, according to researchers.
In addition, for every six patients who were treated with a placebo rather than RAINS, only one additional patient will the benefit in the short term. People who take the drug RAINS has also a high-risk channel cornea side effects. Patients may want to consider, if this seems like a viable option to take.
NSAIDS currently recommended for treatment of back pain, but the authors suggest new and more effective drugs should be developed as soon as possible.
Funding provided by the Department of education and training in Australia, national health and medical research Council of Australia and the Sydney Medical School.
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